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Angiderm is indicated for the prevention and treatment of anginal pectoris due to coronary artery
diseases and considered specially useful for preventing early morning heart attacks. Angiderm provides
continueous controlled release of nitroglycerin through intact skin.
Description
Angiderm patch is designed to deliver nitroglycerin continuously and consistently over 24-hour period
upon application to intact skin. Two strengths of Angiderm systems are available, having nominal in vivo
delivery of 0.2 and 0.4mg nitroglycerin per hour through skin of average permeability.
Angiderm systems have contact surface areas of 7 and 14 and contain 22.4 and 44.8mg of nitroglycerin
respectively.
Indication and Usage
Prevention and treatment of anginal pectoris due to coronary artery diseases and considered specially
useful for preventing early morning heart attacks.
Angiderm provides continueous controlled release of nitroglycerin through intact skin.
Features
 Ideal not only for the treatment but the prevention of angina pectoris
(especially useful for early morning heart attack).
Avoid occurrence of gastric irritation and liver toxicity by delivering nitroglycerin directly to
blood through skin.
Consistent nitroglycerin delivery across the dosing period.
Consistently well tolerated.
Low skin irritation.
hin, flexible, virtually transparent matrix patch.
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What is angina pectoris?
Angina pectoris is the medical term for chest pain due to coronary heart disease. Angina is a symptom of a condition
called myocardial ischemia . It occurs when the heart muscle (myocardium) doesn't get
as much blood (hence as much oxygen) as it needs for a given level of work. Insufficient blood supply is
called ischemia.
When does angina pectoris occur?
Angina pectoris can occur when blood flow to the heart is enough for normal needs but not enough
when the heart's needs increase. Running to catch a bus, for example, could trigger an attack of
angina while walking to a bus stop might not. It may happen during physical exercise,
strong emotions or extreme temperatures. Some people, such as those with a coronary artery spasm ,
may have angina
when they're resting. (See below, Prinzmetal's or variant angina pectoris.)
Angina is a sign that someone is at increased risk of heart attack.
What is variant angina pectoris (Prinzmetal's angina)?
Variant angina pectoris is also called Prinzmetal's angina. Unlike typical angina, it occurs almost exclusively
when a person is at rest, and it doesn't follow a period of physical exertion or emotional stress. Attacks
can be very painful and usually occur between midnight and 8 a.m. It's associated with
acute myocardial infarction (heart attack).
severe cardiac arrhythmias .
These may include ventricular tachycardia and fibrillation .
sudden cardiac death.
Variant angina is due to coronary artery spasm . About two-thirds of people with it have severe coronary
atherosclerosis in at least one major vessel. The spasm usually occurs very close to the blockage.
Many people with Prinzmetal's angina go through an acute, active phase. Anginal and cardiac events
may occur often for six months or more. During this time, nonfatal myocardial infarction occurs in up to 20
percent of patients; death occurs in up to 10 percent. People who develop serious heart rhythm
disturbances (arrhythmias) at this time are at greater risk of sudden death.
Most people who survive an infarction or this initial three- to six-month period stabilize, and symptoms
and cardiac events tend to diminish over time. Long-term survival is excellent, ranging from 89 to 97
percent
at five years. Patients without significant obstructive coronary artery disease have an excellent
long-term outlook.
The ergonovine test is the most sensitive and useful test for coronary spasm. In this test, the ergonovine
is administered to induce coronary spasm. Hyperventilation and coronary injections of acetylcholine are
other means used to provoke variant angina during cardiac testing.
What drugs are used to treat angina pectoris?
Angina pectoris can be treated with drugs that affect
1) the supply of blood to the heart muscle or
2) the heart's demand for oxygen.
Examples of drugs affecting blood supply are coronary vasodilators , which cause blood vessels to relax.
When this happens, the opening inside the vessels (the lumen) gets bigger. Then blood flow improves,
letting more oxygen and nutrients reach the heart muscle.
Nitroglycerin is the drug most often used. It relaxes the veins (reducing the amount of blood that returns
to the heart and easing the heart's workload) and the coronary arteries (increasing the heart's
blood supply). The heart's demand for oxygen also can be modified by prescribing a drug to reduce blood
pressure. This reduces the heart's workload and need for oxygen by lowering resistance to flow.
Drugs that slow the heart rate achieve a similar effect
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Customer services |
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Person in charge : M.H. Kim
Address : 263 Yeonji-dong, Jongno-gu, Seoul 110-725, Korea
Tel : 82-2-740-7295 Fax : 82-2-743-6626
E-mail : marie@samyang.com |
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