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Estran Patch is a hormone replacement therapy (HRT) system that providers transdermal delivery of
estradiol. Estran is indicated for relief from postmenopausal symptoms.
Description
Estran patch are designed to deliver 17-estradiol continuously and consistently over a 3 to 4 day interval upon application to intact skin.
Three strengths of Estran systems are available, having nominal in vivo delivery of 0.05, 0.075,
and 0.1mg estradiol per day through skin of average permeability (inter-individual variation in skin
permeability is approximately 20%).
Estran systems have contact surface areas of 18, 27, and 36 and contain 1.5, 2.3, and 3.0mg of
estradiol, USP, respectively. |
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| Product name |
Active Ingredient (per patch) |
Release Rate (in 24hours) |
ESTRAN 50
ESTRAN 75
ESTRAN 100 |
Estradiol 1.5mg
Estradiol 2.3mg
Estradiol 3.0mg |
0.05mg
0.075mg
0.1mg |
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Indication and Usage
Treatment of post-menopausal symptoms (hot flushes, insomnia, nervous symptoms or depression which might
occur during menopause, vulval and vaginal atrophy) and bone loss, caused by natural process
or an operation.
Menopausal symptoms
During menopause, the production of estrogen decreases well below normal level.
The resulting set of physiological and psychological changes are defined as postmenopausal symptoms.
In many women this decrease in estrogen production causes uncomfort, most noticeably hot flushes and
sleep disturbances. Some women may also develop other changes
such as impaired bladder controls and vaginal dryness that cause discomfort during and after intercourse. Estrogen can be given to
reduce or
eliminate these symptoms and bone loss associated with menopause.
Reference
 Climacteric, 2(1), 1999, 29-36
Menopause, 5(2), 1998, 107-112
Mayo Clinic Proceeding, 69 (2), 1994, 131-135
Arterioscler. Thromb. Vasc. Biol., 17(11), 1997, 3071-3078
Dosage & Administration
Apply one patch twice per week on the back or lower abdomen.
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Customer services |
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Person in charge : M.H. Kim
Address : 263 Yeonji-dong, Jongno-gu, Seoul 110-725, Korea
Tel : 82-2-740-7295 Fax : 82-2-743-6626
E-mail : marie@samyang.com |
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