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Active Ingredient
Paclitaxel

Genexol PM is a patented new formulation of paclitaxel developed by Samyang.
The new formulation is free from toxic surfactant and allows significantly higher dosing of paclitaxel to the patients

Indication
▪ First-line therapy for the treatment of metastatic or recurrent breast cancer
▪ First-line therapy for the treatment of locally advanced or metastatic non-small cell lung cancer

Dosage and Administration
1) Breast cancer
    Genexol-PM is administered at a dose of 300mg/m2 intravenously over 3 hours every 3 weeks.
2) Non-small cell lung cancer
    Genexol-PM is administered over 3 hours intravenously according to the dose below, followed by
    cisplatin at a dose of 60mg/m2 intravenously.
    ▪ Dose of Genexol-PM for first cycle : 230mg/m2
    ▪ Dose of Genexol-PM for second cycle and more

Package
Paclitaxel 30mg/vial, 100mg/vial

The goal of polymeric micelle technology is to enhance solublization of water insoluble drugs to facilitate formulation of therapeutically more effective products.

Samyang’s proprietary biodegradable polymers such as poly(ethylene glycol)-poly(lactic acid) block copolymers have specific functionality. These polymers have strong potential for the development of self-forming nanometer-size(<50nm) micelle particles which can be administered directly to the specific sites and release the incorporated or entrapped drug in a sustained manner. Samyang’s proprietary polymeric micelle technology is being evaluated as a potential formulation strategy for systemic or local delivery of highly water insoluble drugs.

Testing to date has demonstrated significant pharmaceutical and biological advantages for polymeric micelle formulations as compared to standard preparations. The technology enables development of pharmaceutically acceptable formulations with enhanced stability and improved bioavailability of highly water insoluble drugs. Additional potential of the technology may be realized for manipulating pharmacokinetic parameters and distribution of drug in tissues.

Customer services
Person in charge : M.H. Kim
Address : 263 Yeonji-dong, Jongno-gu, Seoul 110-725, Korea
Tel : 82-2-740-7295 Fax : 82-2-743-6626
E-mail : marie@samyang.com
Copyright 2005 by Samyang Corporation. All rights reserved.